大学で本を借りる
Here we report a unique cellular reprogramming phenomenon, called stimulus-triggered acquisition of pluripotency (STAP), which requires neither nuclear transfer nor the introduction of transcription factors. In STAP, strong external stimuli such as a transient low-pH stressor reprogrammed mammalian somatic cells, resulting in the generation of pluripotent cells. Through real-time imaging of STAP cells derived from purified lymphocytes, as well as gene rearrangement analysis, we found that committed somatic cells give rise to STAP cells by reprogramming rather than selection. STAP cells showed a substantial decrease in DNA methylation in the regulatory regions of pluripotency marker genes. Blastocyst injection showed that STAP cells efficiently contribute to chimaeric embryos and to offspring via germline transmission. We also demonstrate the derivation of robustly expandable pluripotent cell lines from STAP cells. Thus, our findings indicate that epigenetic fate determination of mammalian cells can be markedly converted in a context-dependent manner by strong environmental cues.
・最初は、こんな臨床ではない研究を読めるかなと思っていましたが、案外読めました。さすが、Natureにいったん載るだけ有って「読みやすい」＝論文の体裁が整っている。残念ながらmisconductだったのですが．．．
・今日久々（１年ぶり？）に大学に「登校」したのは↓の本を借りるためです。（教室のセミナー室に貸しだし用に何冊もならんでします）
- 出版社/メーカー: 日本評論社
- 発売日: 2004/10/01
- メディア: 単行本
- 出版社/メーカー: 日本評論社
- 発売日: 2008/04/01
- メディア: 単行本
- 出版社/メーカー: 日本評論社
- 発売日: 2013/08/22
- メディア: 単行本
