抗ＣＣＰ抗体とアルツハイマー病/久々のイオン倉敷
Background: In the hippocampi of Alzheimer's disease (AD) patients, aberrant expression of citrullinated proteins and peptidylarginase 2 (PADI2) has been identified. We explored the functional roles of these proteins by means of detection of serum anti-cyclic citrullinated peptide antibody (anti-CCP antibody) in patients with dementia of Alzheimer's type (DAT).
Methods: Sera were obtained from 42 patients with DAT, 30 patients with other neurological disorders and 42 healthy controls. Gender ratio and age were comparable among the three groups. The level of anti-CCP antibody in sera was examined by ELISA.
Findings: Anti-CCP antibody was not found in the 30 patients with other neurological disorders, and only one of the 42 healthy controls (2.4%) was positive. However, surprisingly, anti-CCP antibody was clearly detected in eight of the 42 DAT patients.
Interpretation: Anti-CCP antibody appears to be a simple and early serologic biomarker for DAT among dementia patients. Additionally, our data imply that citrullinated proteins accumulated in the astrocytes of AD patients acquire neo-antigenicity, inducing anti-CCP antibody production.
・この論文は残念ながら有料なので、本文は見ることができませんでした。関連した他の著者の論文が↓（これはfreeでした）
Background:
Alzheimer's disease (AD) is one of the most important neurodegenerative disorder. Anti-cyclic citrullinated peptide (anti-CCP) may all be involved in the development of vascular disease such as AD. The aim of this study is detection of seropositivity for anti-CCP antibody in AD patients.
Methods:
In our study, 30 patients with AD and 29 healthy controls (age and-sex matched) were recruited. Homocysteine and anti-CCP was measured by spectrophotometrically and immunoassay.
Results:
Mean ± SE anti-CCP was higher significantly between AD (13.6 ± 3) and healthy subjects (4.8 ± 0.2) (P = 0.006). In the patients, anti-CCP serum level was in high range (32.1%) of abnormal levels, but there was no significant difference in serum homocysteine in AD patients compared with controls. There is no correlation between anti-CCP and homocysteine levels in AD patients (P = 0.75), but between age and anti-CCP level observed a significantly correlation (P = 0.04).
Conclusions:
It needs more studies to clarify confirmation the role of anti-CCP antibody production in AD patients.
・アルツハイマー病の方が関節リウマチを疑わす症状を訴えられた場合、検査の解釈は要注意ですね。
以下日記
・本日7/11（土）は、6時10分起床。朝食後10時半くらいまでお勉強しました。11時前に家を出てイオン倉敷へ。MOVIXで、『レイニーデイ・イン・ニューヨーク』を観ました。ところどころ薬と笑えましたが、ラストが予想できたのと、こんなラストでよいのと、ちょっと今一でした。（あくまで個人の感想です）
・音楽はかなりよかったなと思うのですが、ちょっとだけネットでみただけですがあまり音楽のことにふれた記事は見られなかったです。
・映画の後は配偶者とおちあい、回転寿司で昼食。その後イオン内をちょっとぶらついて、すこしだけ買い物して16時20分帰宅。一服後ちょっとお勉強、その後入浴、夕食および飲酒。で、このブログを書いております。これが終わったら歯磨きして、ちょっとだけ調べ物して寝ます。
